Oral & Overall health

Evidence that links Oral Health to Overall Health

Regularly scheduled oral evaluations are an extremely important part of your overall healthcare.  There are several reasons this is true.

First, oral exams allow your dentist to monitor your oral and overall health for emerging problems that you may not see or feel. These may be dental conditions, like tooth decay, gingivitis, and periodontal disease, or emerging medical conditions that have oral manifestations, like oral cancer, cardiovascular disease, diabetes, hypertension, and even some other cancers of the body. During a dental evaluation, your dentist may recognize these oral manifestations and refer you to a healthcare professional for evaluation, diagnosis, and treatment.

Second, many health conditions, medications, and treatments can negatively impact your oral health.  It is important to understand which conditions, medications, and treatments can put your oral health at risk. Through regular dental visits, you can better manage these risks.

Third, dental disease, most notably periodontal disease, has been linked to a broad spectrum of health conditions. The following are recent studies that are beginning to clarify the nature of the oral-systemic connection.

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Last updated July 2025

General

General

Our results suggest that Neutrophil percentage-to-albumin ratio (NPAR) is significantly linked to poor periodontal health. However, owing to the cross-section design of this study, additional longitudinal studies are necessary to further enhance our comprehension of the impact of NPAR on periodontal status.

International Dental Journal

2025

Our results suggest that Neutrophil percentage-to-albumin ratio (NPAR) is significantly linked to poor periodontal health. However, owing to the cross-section design of this study, additional longitudinal studies are necessary to further enhance our comprehension of the impact of NPAR on periodontal status.

International Dental Journal

2025

These findings demonstrate that approximately 75% of patients, independently from their socio-economic status, periodontal health status, frequency of dental visits and perceived access to care, still ignored the link between periodontitis and other diseases. The level of awareness was low even among patients suffering from periodontitis or from cardiovascular diseases, cancer and diabetes, which have been extensively associated with periodontitis

Periodontology

2024

This article gives an overview of the societal and economic aspects of periodontitis and periodontal care.

Periodontology

2024

Self-reported oral health had a similar magnitude of associations with systemic comorbidities as established with periodontal disease previously. Moreover, self-rated fair or poor oral health, suboptimal dental visits, or infrequent flossing were associated with increased all-cause mortality.

JADA

2024

This study aims to investigate the link between oral health and mortality in community-dwelling older adults by adjusting for confounding factors with a doubly robust survival estimation. Edentulism was associated with a reduction in survival time.

American Journal of Preventive Medicine

2022

Time-varying periodontal status assessed using radiographic alveolar bone loss (ABL) was positively associated with all-cause mortality even after confounder adjustment.

Journal of Clinical Periodontology

2022

Preventive dental care is strongly associated with significant savings for diabetes and CAD patients, and such savings were highest for diabetes + CAD patients, followed by patients with only CAD and only diabetes. Most of these savings originated in costs associated with inpatient admissions, which were between 25% and 36% for all disease classifications for all years.

Compendium of Continuing Education in Dentistry

2022

Maintaining oral health is essential to general health and well-being. Oral conditions affect more than just the mouth and teeth. Poor oral health increases the risk of developing chronic conditions, such as cardiovascular disease and diabetes.

Pharmacy Times

2022

In this cohort, periodontal diseases appeared to be associated with an increased risk of developing cardiovascular, cardiometabolic, autoimmune diseases and mental ill health. Periodontal diseases are very common; therefore, an increased risk of other chronic diseases represent a substantial public health burden.

BMJ Journals

2021

Sheds important new light on why some people may be more prone to serious conditions that lead to tooth loss and other problems.

PNAS

2021

Observed that accessing preventive dental care by a large cohort of publicly insured individuals in New York State was associated with better health care outcomes, most notably for the rates and costs of inpatient admissions.

Journal of Dental Research

2021

Provides clinical rationale for perio-systemic disease links

Journal of Dental Research

2020

Provides support of correlative; not causative perio-systemic links

CDC – Systematic Review (Volume 16)

2019

Diabetes

Diabetes

The possible association between Diabetes mellitus (DM), xerostomia, and/or hyposalivation is complex and may be influenced by multiple factors.

Journal of Oral Pathology and Medicine

2024

Type 2 diabetes may lead to an increased index of dental caries and a reduction in salivary flow rate, salivary pH, and salivary buffering capacity in adults.

Journal of Dentistry

2024

Diabetic neuropathy and retinopathy, individually and combined, were associated with moderate/severe periodontitis. In addition, dyslipidemia had an additive positive effect modification on diabetic microvascular complications, elevating the odds of moderate/severe periodontitis.

Sage Journals

2024

Periodontal disease was associated with insulin resistance and metabolic syndrome (MetS) in women at prior high risk of developing gestational diabetes.

Clinical and Experimental Dental Research

2024

This study provides a significant contribution of periodontal disease (PD) to the increase in health care expenditure (HCE), particularly in individuals with diabetes mellitus (DM).

Journal of Periodontology

2025

Using oral health care preventive services and visits to a dentist or dental clinic for problems during pregnancy was associated with decreased odds of having gestational diabetes and hypertensive disorders of pregnancy.

Journal of the American Dental Association (JADA)

2025

Regular periodontal disease prevention and management under professional care before type 2 diabetes mellitus onset contribute to improved health and reduced medical costs.
Primary Care Diabetes (PCDE)

 

2024

Periodontal disease (PD) poses a high risk of suffering from gestational diabetes mellitus (GDM). The development of oral health programs in women who wish to conceive is essential to improve metabolic control and reduce obstetric and perinatal complications.
Primary Care Diabetes (PCDE)

 

2024

The triglyceride-glucose (TyG) index was associated with increased odds of moderate / severe periodontitis, especially in individuals with obesity, hypertension, and dyslipidemia. Systolic blood pressure (SBP) levels partially mediated this association.

Journal of Periodontal Research

2024

Results suggest that gargling with mouthwash reduces the number of red complex species and improves the hyperglycemic status in patients with type 2 diabetes mellitus, especially younger patients.

Scientific Reports

2024

We included 35 studies, which randomised 3249 participants to periodontal treatment or control.

Cochrane Library

2022

T1DM negatively affected enamel and dentine microhardness, and enamel was influenced much more negatively and rapidly compared with dentine in diabetic groups.

Archives of Oral Biology

2022

Preventive dental care is strongly associated with significant savings for diabetes and CAD patients, and such savings were highest for diabetes + CAD patients, followed by patients with only CAD and only diabetes.

Compendium of Continuing Education in Dentistry

2022

The findings suggest that T2D is associated with increased risk of tooth loss.

BMC Endocrine Disorders

2022

Frequent tooth brushing was associated with reduced risks of incident hypertension and T2DM. Tooth brushing at least twice a day may prevent future hypertension and T2DM events.

Journal of Hypertension

2022

Findings suggest that improvement in oral health, including the maintenance of masticatory function and remaining teeth, may contribute to the prevention of sarcopenia and diabetes mellitus in older adults.

PLOS One

2021

There is moderate certainty for a small but significantly higher risk of tooth loss in Diabetes patients as compared to those without Diabetes.

International Journal of Dental Hygiene

2021

Diabetes mellitus may affect the physical and mechanical properties of dentin, which could potentially have an impact on root canal procedures.

Journal of Endodontics

2021

Implementation of an oral care protocol in primary diabetes care improved oral health–related quality of life in patients with type 2 diabetes

Annals of Family Medicine

2021

Provides evidence that oral hygiene reduces new onset T2D

Springer Verlag

2020

In this systematic review and meta-analysis, there is a significant reduction of Glycated hemoglobin and Fasting plasma glucose level on type 2 diabetic and periodontal patients with non-surgical periodontal therapy.

BMC Oral Health

2016

Supporting evidence that perio treatment improves T2D control

Journal of Clinical Periodontology

2013

Provides evidence to suggest that perio disease adversely affects diabetes outcomes

Journal of Clinical Periodontology

2013

Cardiovascular disease

Cardiovascular Disease

In this review, we summarized clinical findings on the association between periodontitis and thrombotic diseases and discussed several novel prothrombotic periodontitis-related agents, and presented a perspective to emphasize the necessity of oral health management for people at high risk of thrombosis.

International Journal of Oral Science

 

2024

Oral health behavior associated with cardiometabolic outcomes: A nationally representative cross-sectional study in Portugal

Individuals with poor oral health behavior had a higher prevalence of diabetes and high/very high cardiovascular risk. Sensitivity analysis suggested that regular tooth brushing may be the main behavior for preventing diabetes and cardiovascular risk. The results suggest that regular tooth brushing may act in prevention for diabetes and cardiovascular risk.

International Journal of Cardiology

 

2025

  • People who regularly floss their teeth (1+ times per week) may lower their risk of stroke caused by a blood clot traveling from the heart and a stroke associated with an irregular heartbeat such as atrial fibrillation (AFib).
  • The benefits of regular flossing may be independent of tooth brushing and other oral hygiene behaviors.
  • Researchers suggest that flossing is a healthy habit that is affordable, easy to adopt and accessible everywhere.

 

American Stroke Association International Stroke Conference 2025 - Abstract 19

 

2025

  • Increased levels of Streptococcus anginosus, a common type of bacteria that usually lives in the mouth and gut, was found in the gut of recent stroke survivors in Japan.
  • Over two years, stroke patients with a significant amount of Streptococcus anginosus bacteria in their gut were more likely to die or have another major cardiovascular event than stroke patients without Streptococcus anginosus in the gut.
  • The results suggest that analyzing mouth and gut bacteria may someday help determine stroke risk, and that targeting these harmful bacteria with new therapies and proper dental hygiene may help prevent stroke.

 

American Stroke Association International Stroke Conference 2025 - Abstract 106

 

2025

The qualitative positivity for Fusobacterium nucleatum in the oral cavity was independently associated with high-grade white matter hyperintensities and high-grade total cerebral small vessel disease (CSVD) score in patients with ischemic stroke. Thus, oral care targeting Fusobacterium nucleatum may aid in impeding CSVD progression.
Journal of Stroke and Cerebrovascular Diseases

 

2024

The present systematic review reported that being edentulous or having lesser than 10 teeth is a predictive indicator of Cardiovascular Disease (CVD) mortality.

Journal of Endodontics

2024

The triglyceride-glucose (TyG) index was associated with increased odds of moderate / severe periodontitis, especially in individuals with obesity, hypertension, and dyslipidemia. Systolic blood pressure (SBP) levels partially mediated this association.

Journal of Periodontal Research

2024

Our findings indicate that there is no genetic causal association between periodontitis and infective endocarditis.

International Dental Journal

2024

Oral problems were associated with sarcopenic obesity in post-stroke. Oral assessment and intervention may have a positive impact on Activities of Daily Living (ADL) and Quality of Life (QOL) in post-stroke patients with sarcopenic obesity.

Wiley

2024

Periodontitis and recent invasive dental procedures were associated with Cryptogenic Ischemic Stroke (CIS) after controlling for multiple confounders.

Sage Journals

2024

Results identified the crucial role of γδ T-M2 immune mechanism in mediating periodontitis-promoted COPD progression.

mSystems

2024

  • Having decayed, filled and/or missing teeth was tied to increased risk for stroke and death.
  • Risk was especially high among Black individuals compared with white individuals.

Helio

2023

Specific oral bacteria are associated with baseline blood pressure status and risk of hypertension development among postmenopausal women. Research to confirm these observations and elucidate mechanisms is needed.

Journal of the American Heart Association

2023

We found that whole mouth oral inflammatory load was a predictor of reduced flow-mediated dilation. An impairment in flow-mediated dilation is an indicator of future possible risk of cardiovascular disease—one of the leading causes of death in North America.

Frontiers

2023

The authors histologically revealed the association of periodontitis with atrial fibrosis. This indicates that periodontitis, which is modifiable, is likely a risk factor for atrial fibrillation.

Journals of the American College of Cardiology

2022

Periodontal status was associated with incident heart failure, heart failure with preserved ejection fraction, and heart failure with reduced ejection fraction, as well as unfavorable changes in C-reactive protein and congestion.

JACC: Heart Failure

2022

Preventive dental care is strongly associated with significant savings for diabetes and CAD patients, and such savings were highest for diabetes + CAD patients, followed by patients with only CAD and only diabetes.

Compendium of Continuing Education in Dentistry

2022

We found that periodontal care was associated with more after acute myocardial infarction (AMI) visits. This suggests that there is a benefit to incorporating oral health care and medical care to improve AMI outcomes.

Journal of the American Dental Association

2022

Adults with a recorded diagnosis of a periodontal disease, including gingivitis and periodontitis, are more likely to develop CVD and other chronic diseases compared with patients without a diagnosis.

Healio

2022

Study concluded that specific oral bacteria are associated with baseline blood pressure status and risk of hypertension development among postmenopausal women.

Journal of the American Heart Association

2022

Frequent tooth brushing was associated with reduced risks of incident hypertension and T2DM. Tooth brushing at least twice a day may prevent future hypertension and T2DM events.

Journal of Hypertension

2022

Intensive gum disease treatment failed as a measure of secondary prevention for stroke survivors in the "stroke belt" of the U.S., a randomized study found.

PREMIERS

2022

This study aimed to evaluate the causal association of periodontal disease with acute myocardial infarction (AMI) and stroke, after controlling for various confounders among the Korean population. Our data confirmed that severe periodontal disease was causally associated with the new events of AMI and stroke.

Journal of Dental Research

2021

The results of this study suggest that elimination of oral infection prior to cardiovascular surgery does not increase the risk of morbidity or mortality.

Journal of Oral and Maxillofacial Surgery

2021

Streptococcal bacteria, mostly of oral origin, may contribute to the progression and thrombotic events of cerebrovascular diseases.

Journal of the American Heart Association

2021

Those who kept up with routine dental care had lower risks of atrial fibrillation than those who only went to the dentist when they experienced discomfort or needed dental work or who failed to keep a regular appointment schedule

American Heart Journal

2021

Study aimed to investigate the relationship between periodontitis and mean arterial blood pressure in a sample of otherwise systemically healthy individuals.

Hypertension

2021

Rheumatoid arthritis (RA) patients have elevated rates of perio and cardiovascular disease, suggesting that their immune responses to gum disease bacteria may be linked to higher heart disease risk.

Arthritis and Rheumatology

2020

Reports a significant association between dental caries and intracerebral hemorrhage (ICH).

Stroke

2020

Provides consistent and strong epidemiologic evidence that periodontitis increased risk for future cardiovascular disease

Journal of Clinical Periodontology

2013

Pregnancy

Pregnancy

Scaling and root planning (SRP) with mouthwash use during pregnancy were associated with significantly lower risks of preterm birth (PTB) and low birth weight (LBW).

 

BMC Pregnancy and Childbirth

2024

The study sample showed relatively positive self-perceived oral health and dental visit patterns. However, the low rate of dental visits during pregnancy highlights the need for better integration of dental care into prenatal care.

 

International Dental Journal

2024

Pre-term (PT) children are at higher risk for developmental defects of enamel (DDE) in primary teeth and compromised periodontal health than full-term (FT) children. Children with extremely low birthweight (ELBW) are most susceptible for dental caries and gingivitis.

 

Dentistry Journal

2024

Using oral health care preventive services and visits to a dentist or dental clinic for problems during pregnancy was associated with decreased odds of having gestational diabetes and hypertensive disorders of pregnancy.

 

Journal of the American Dental Association (JADA)

2025

High birth weight is a risk factor for early childhood caries. Particular attention should be paid to children with birth weight more than or equal to 4,000 g.

 

BMC Oral Health

2024

The oral microbiome is associated with stress and mental health in pregnant women, in ways different from the gut microbiome or what has been found in non-pregnant people.
BMJ Mental Health

2024

Periodontal disease (PD) poses a high risk of suffering from gestational diabetes mellitus (GDM). The development of oral health programs in women who wish to conceive is essential to improve metabolic control and reduce obstetric and perinatal complications.
Primary Care Diabetes (PCDE)

2024

It was observed a high prevalence of periodontal disease in pregnancy.

Journal of Dentistry

2022

The study results indicate that periodontitis is strongly associated with premature birth. Preventive solutions including the use of a periodontitis screening tool for nurses and midwives during antenatal care consultations, are highly recommended.

BMC Pregnancy and Childbirth

2021

Systematic review supports a low but existing association between perio and adverse pregnancy outcomes

National Library of Medicine

2016

In this article we describe the importance of the recognition, prevention, and treatment of oral health problems in pregnant women.

Journal of Obstetric, Gynecologic, & Neonatal Nursing (JOGNN)

2016

Aims to assess epidemiological evidence for the impact of perio disease on adverse pregnancy outcomes and identify potential underlying mechanisms.

Journal of Clinical Periodontology

2013

Alzheimer’s Disease and dementia

Alzheimer’s Disease and Dementia

Denture use may help protect against cognitive decline in older adults with partial tooth loss. This study highlights the potential importance of prosthodontic rehabilitation in preserving cognitive health.

Aging Medicine

2024

Our results confirmed that periodontitis was associated with both intra- and internetwork functional connectivity (FC) changes even in normal cognition (NC). The present study indicates that periodontitis might be a potential risk factor for brain damage and provides a theoretical clue and a new treatment target for the early prevention of Alzheimer disease.

Journal of Periodontology

2024

  • Poor Oral Health Raises the Risk of Being Diagnosed with Alzheimer’s Disease & Related Dementias (ADRD)
  • ADRD Negatively Affects Oral Health and Requires Additional Care
  • Questions Remain about the Relationship Between ADRD and Oral Health
  • Research Can Help Fill in the Knowledge Gaps

CareQuest Institute for Oral Health

2024

Patients with periodontal disease are significantly more likely to develop Alzheimer’s disease than those who are periodontally healthy. This interaction is thought to be mediated by inflammation, the periodontal microbiome, and the immune reactions to those pathogens that are associated with the oral biofilm.

Dental Academy of Continuing Education

2023

Our study finds the co-occurrence of Diabetes mellitus (DM) and edentulism led to a worse cognitive function and a faster cognitive decline in older adults aged 65 to 74.

Sage Journals

2023

Poor periodontal health and tooth loss appear to increase the risk of both cognitive decline and dementia. However, the available evidence is limited to draw firm conclusions.

Journal of the American Geriatrics Society

2022

This review suggests that periodontal infection is associated with Alzheimer’s Disease. The contributing microbiome remains unconfirmed, possibly because of different microbiome sampling sites or methods.

Journal of Dental Sciences

2022

The findings provide a theoretical basis for the study of the relationship between F. nucleatum and AD and lay a preliminary foundation for further exploring the mechanism of F. nucleatum impact on the onset and development of Alzheimer’s Disease

Frontiers

2022

Moderate-quality evidence suggested tooth loss was independently associated with cognitive impairment and dementia; risk of diminished cognitive function increased with incremental numbers of teeth lost. Further, timely prosthodontic treatment with dentures may reduce the progression of cognitive decline related to tooth loss.

Journal of Post-Acute and Long-Term Care Medicine

2021

PAP treatment and adherence are independently associated with lower odds of incident AD diagnoses in older adults. Results suggest that treatment of OSA may reduce the risk of subsequent dementia.

Sleep

2021

The results of the present study using Japanese dental claims data showed that older people visiting dental offices with fewer teeth present and a greater number of missing teeth are more likely to have Alzheimer’s disease.

PLOS One

2021

To our knowledge, this is the first report of an association between subgingival periodontal bacteria and CSF biomarkers of AD pathology in cognitively normal elderly people. We found that subgingival periodontal dysbiosis characterized by increases in periodontal‐associated bacteria and decreases in health‐related bacteria associated with reduced CSF Aβ42 but not with CSF P‐tau.

Alzheimer’s Association

2021

Supports a modest association between perio disease and incidence of mild cognitive impairment and dementia

Neurology – American Academy of Neurology

2020

This study provides evidence for an association between periodontal pathogens and AD, which was stronger for older adults.

Journal of Alzheimer’s Disease

2020

Evaluates the mechanisms underlying the potential link between perio disease and Alzheimer’s disease

Science Advances -- American Assoc for the Advancement of Science

2019

Evaluates the potential link between perio disease and Alzheimer’s disease with goal of identifying novel mechanisms and interventional strategies to improve patient outcomes

NIH – US Library of Medicine

2015

Osteoporosis

Osteoporosis

Tooth loss and dental decay rates were significantly high in patients with osteoporosis. Although bone resorption during osteopenia is not excessive, it constitutes a crucial risk factor for dental health.

BMC Oral Health

2025

Low bone mass was associated with the risk of Periodontal Disease among young adults

International Journal of Environmental Research and Public Health

2021

Evidence from (97) prospective studies supports the contention that individuals with osteoporosis may be at increased risk for the manifestations of oral osteoporosis; however, such risk is not definitively proven.

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology

2005

Kidney Disease

Kidney Disease

Found that select measures of periodontal disease were associated with incident low estimated glomerular filtration rate (eGFR)

International Journal of Environmental Research and Public Health

2021

This article reviews the current understanding of the oral and dental aspects of chronic renal disease (CRD).

The Saudi Dental Journal

2015

Psoriasis

Psoriasis

Atopic dermatitis (AD) appears to be associated with poor oral health and oral dysbiosis.

International Dental Journal

2024

The aim of this meta-analysis was to quantitatively evaluate whether the periodontal status of psoriasis patients is worse than that of nonpsoriasis subjects.

Frontiers in Medicine

2019

Anxiety and Depression

Anxiety and Depression

The results suggested that there were interactive effects between smoking, drinking and depression on periodontitis risk and policies aimed at healthy behaviors and mental health may be beneficial for our oral health.

BMC Oral Health

2024

The purpose of this systematic review and meta-analysis was to assess the prevalence of psychological disorders in patients with temporomandibular disorders (TMDs). Patients with TMDs who seek clinical care show a high prevalence of depression and somatization.

The Journal of Prosthetic Dentistry

2022

In this cohort, periodontal diseases appeared to be associated with an increased risk of developing cardiovascular, cardiometabolic, autoimmune diseases and mental ill health.

BMJ Open

2022

The present study identified that there is a communication between some oral health conditions (xerostomia and tooth loss) and the prevalence of depressive disorders in institutionalized old people.

SciFlo Brazil

2021

Cognitively impaired subjects among older adults in Finland have more carious teeth, are more often edentulous without using a denture, and have poorer denture hygiene than cognitively healthy persons.

Taylor and Francis Online

2021

There was a positive and significant association between chronic gingivitis and depression in the overall sample. These findings were corroborated in men and women and in all age groups except patients 65+ years.

Journal of Psychiatric Research

2021

The results of our study have shown that among people aged 65 and over, the severity of depression increases with a higher number of missing teeth, the number of decayed teeth, as well as prevalence of oral dryness.

Medicine

2018

Arthritis

Arthritis

This work highlights how Rheumatoid Arthritis (RA) can be progressed by inflammasome activation as a result of periodontitis-associated bacterial infection and discusses the mechanism of inflammasome activation in response to infection with A. actinomycetemcomitans.

International Journal of Oral Science

2024

The results suggest that (i) periodontal disease results in repeated breaches of the oral mucosa that release citrullinated oral bacteria into circulation, which (ii) activate inflammatory monocyte subsets that are observed in inflamed RA synovia and blood of rheumatoid arthritis patients with flares and (iii) activate ACPA B cells, thereby promoting affinity maturation and epitope spreading to citrullinated human antigens.

Science Translational Medicine

2023

An elevated prevalence and frequency of dental visits were associated with patients with Rheumatoid Arthritis. In addition, elevated incidence of dental disorders, including dental caries, pulpitis, gingivitis, periodontitis, and oral ulceration, were observed.

BMC Oral Health

2022

This hypothesis-testing study evaluated the relationship between mercury (Hg)-based dental amalgams and arthritis diagnoses among US adults. A significant association between dental amalgam filling surface (DAFS) and arthritis risk and a dose-dependent DAFS associated immune-stimulation / immune-suppression with arthritis risk were observed.

Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders

2021

The results show similarities in the oral microbiome between ERA patients and at-risk individuals, both presenting with increased relative abundance of potentially pro-inflammatory species compared to healthy controls, suggesting a possible association between the oral microbiome and RA onset.

Arthritis Rheumatol

2021

Rheumatoid arthritis (RA) patients have elevated rates of periodontal and cardiovascular disease, suggesting that their immune responses to gum disease bacteria may be linked to higher heart disease risk.

Arthritis and Rheumatology

2020

Aims to determine sequences and magnitude of causality among perio disease, diabetes and chronic kidney disease

Journal of Clinical Periodontology

2020

This article reviews the current understanding of the oral and dental aspects of chronic renal disease (CRD).

Saudi Dental Journal (republished on US National Library of Medicine -- NIH)

2015

Evaluates the potential link between perio disease and rheumatoid arthritis with goal of identifying novel mechanisms and interventional strategies to improve patient outcomes

NIH – US Library of Medicine

2013

Cancer

Cancer

This case-control study yielded compelling evidence that oral bacteria are a risk factor for head and neck squamous cell cancer (HNSCC) development. The identified bacteria and bacterial complexes hold promise, along with other risk factors, to identify high-risk individuals for personalized prevention of HNSCC.

Journal of the American Medical Association (JAMA)

2024

For patients with head and neck cancer (HNC), implants in the irradiated upper jaw may have lower survival rates than those placed in the lower jaw.

Oral and Maxillofacial Surgery Clinics of North America

2024

Collectively, our findings uncovered complex alterations in the oral microbiome in Oral Squamous Cell Carcinoma (OSCC), providing novel insights into disease etiology and paving the way for microbiome-based diagnostic and therapeutic strategies.
American Society for Microbiology Journal

2025

The degree of alveolar bone loss, as determined by orthopantomogram (OPG), and dental health-related quality of life (HRQoL) both obtained at the time of head and neck squamous cell carcinoma (HNSCC) diagnosis, predicted long-term survival. When analyzed simultaneously, both factors remained significant in both univariate and multivariate analyses, adjusted by pertinent clinical variables, highlighting their unique prognostic value.

BMC Oral Health

2024

A simple oral rinse could provide early detection of gastric cancer, the fourth-leading cause of cancer deaths worldwide, according to a study scheduled for presentation at Digestive Disease Week® 2024.

Press Release

2024

Human papillomavirus (HPV) infection and cervical cancer (CC) impact both the vaginal and oral microenvironments, affecting systemic metabolism and the synergy between bacteria. This suggests that the use of oral flora markers is a potential screening tool for the diagnosis of CC.

Journal of Translational Medicine

2024

Our results identify the Fna clade bifurcation, show that specifically Fna C2 drives the reported Fn enrichment in human colorectal cancer (CRC), and reveal the genetic underpinnings of pathoadaptation of Fna C2 to the CRC niche

Nature

2024

We report here that the function of the Ca2+ channel ORAI1 is an important regulator of oral cancer pain.

Science Signaling

2023

Evaluates the impact of periodontal disease on the development of oral cancer

PLOS Pathogen

2020

Concludes that a history of perio disease and possibly higher number of tooth loss may modestly increase the risk of developing colorectal precursor lesions.

American Association for Cancer Research

2020

Oral bacteria appeared to be more abundant in patients with esophageal cancer compared with otherwise healthy controls

Cancer (American Cancer Society)

2020

Provides additional evidence that cancer risk, especially for lung and colorectal cancer, is elevated in individuals with perio disease.

Journal of the National Cancer Institute

2018

Provides a review of the literature to determine the relationships between dental care in the cancer patient to provide strategic suggestions.

NIH -- US Library of Medicine

 

2018

Reviews appropriate care strategies (perio maintenance, extractions) before and after head and neck cancer treatment and strategies to prevent osteoradionecrosis.

NIH -- US Library of Medicine

 

2018

Study findings support the need for further understanding of the effect of periodontal disease on cancer outcomes

Cancer Epidemiology, Biomarkers & Prevention

 

2017

Obesity

Obesity

This cross-sectional study exposed a positive correlation between WWI (weight-adjusted-waist index), WtHR (waist-to-height ratio), and periodontitis and this positive correlation showed an age difference.

 

Scientific Reports

2025

Orthodontists and dentists should incorporate BMI evaluation in the overall treatment diagnosis and educate patients about the negative impact of obesity on general and oral health.

 

Seminars in Orthodontics

2025

Obesity was associated with a higher prevalence of gingival bleeding, while overweight status showed no significant association. These results suggest that obesity, rather than overweight, is associated with increased gingival inflammation.

 

Obesity Medicine

2024

The authors found no association between measures of adiposity and caries among US children and adolescents.

JADA

2023

Body Mass index (BMI) appears to have a greater impact on relative timing of dental development than ancestry in this population. Our results support other findings that obesity results in accelerated growth and development.

Orthodontics and Craniofacial research

2023

We found that an increase in BMI was associated with a decrease in the number of residual teeth from younger ages independently of smoking status and diabetes in the large scale of Japanese database.

Plos One

2020

Nutrition

Nutrition

The consumption of dietary advanced glycation end products is associated with an increased susceptibility to periodontitis development.

International Dental Journal

2025

A trend towards stabilization of the inflammatory parameters [bleeding on probing (BOP), periodontal inflamed surface area (PISA)] was observed in the whole-food plant-based diet (WPBD) group. Because of the non-significant changes within the groups, this study highlights the imperative for future studies.

Journal of Clinical Periodontology

2024

The authors provided evidence of significant associations between certain fatty acids and periodontitis and its severity, highlighting their contributory role, although the evidence does not support a causal role based on the results of Mendelian randomization (MR)-based analyses.

Journal of the American Dental Association

2025

These findings suggest that short-term juice consumption may negatively affect the microbiota.

Nutrients

2025

Taken together, we present a proof of concept, based on the multimodal inhibitory effect of (a mouthwash containing matcha, a finely ground powder of green tea) against P. gingivalis, and that matcha may have clinical applicability for prevention and treatment of periodontitis.

Microbiology Spectrum

2024

Resveratrol (an antioxidant) decreased bacterial viability and counts of mutans streptococci in vitro. However, in the clinical study involving healthy volunteers, resveratrol did not alter the diversity or abundance of microorganisms in the oral microbiome.

Journal of Dentistry

2024

D-mannose can alleviate chronic periodontitis in rats by regulating the functions of neutrophils, potentially associated with the expression of translocation 2 (TET2) and glycolysis, providing new insights into the potential application of D-mannose to chronic periodontitis.

BMC Oral Health

2024

Older adults with low or very low food security had greater odds of being edentulous compared to those with marginal or high food security, although the difference was not statistically significant.

Journal of Public Health Dentistry

2024

Structural Equation Modeling revealed that oral condition was positively correlated with nutritional status, and nutritional status was positively correlated with the World Health Organization-5 Well-Being Index. These findings suggest that oral condition may influence subjective well-being via nutritional status or social environmental factors.

Plos One

2023

The purpose of this study was to analyze the relations between serum 25-hydroxyvitamin-D [25(OH)D] level and dental caries in children and youth.  The findings suggested that vitamin D sufficiency may be a protective factor for dental caries.

Journal of Public Health Dentistry

2023

Results suggest that certain dietary habits can exacerbate some aspects of periodontitis and that bad periodontal health can contribute to dyslipidemia and promote non-alcoholic fatty liver disease (NAFLD) progression, but only under certain conditions.

MDPI

2020

Additional Connections

Additional Connections

An increased count of fixed prostheses is associated with changes in liver function markers in a gender-dependent manner, with blood lead levels serving as a potential mediator in males.

Environmental Pollution

2024

Findings suggest a significant association between dentofacial characteristics and sleep quality in young adults. Protruding facial profiles and anterior crossbites were identified as independent predictors for sleep disorders (SDs). These findings underscore the importance of screening for SDs in individuals with dentofacial deformities and highlight the potential benefits of early correction of such dentofacial abnormalities to reduce the risk of SDs in adulthood.

BMC Oral Health

2025

In the mouse model, tooth loss disrupted the balance of the oral-gut microbiota, with potential implications for intestinal health. Although these findings are from a murine model, considering the existence of the oral-gut axis balance in the human body, it is reasonable to postulate that following tooth loss in humans, the health of the intestinal microecology may also warrant attention.

BMC Oral Health

2025

Under the conditions of this study, it appears that the odds for acute periapical abscesses (PAs) are significantly higher in patients with periodontal disease (PD) seeking treatment for pain due to acute PAs.

Journal of the American Dental Association

2025

This study underscores the effect of oral microbiota (OM) on epilepsy, suggesting potential mechanisms between the OM and epilepsy. Further investigation into the potential role of the OM is needed to enhance our in-depth understanding of the pathogenesis of epilepsy.

Epilepsia Open

2024

Monitoring bone mineral density (BMD) should be combined with appropriate oral healthcare and caries management strategies to effectively address these interconnected health issues, and particular attention should be paid to the monitoring of head BMD.
Scientific Reports

2024

The findings of this study suggest a significant association between attention deficit hyperactivity disorder (ADHD) and an increased risk of traumatic dental injuries (TDIs). Individuals with ADHD were found to be nearly 2x as likely to experience TDIs compared to those without ADHD.

European Review for Medical and Pharmacological Studies

2024

Patients with periodontitis may be at a much greater risk of developing alopecia areata, an autoimmune disease characterized by hair loss, according to a study published on November 17 in the Journal of the European Academy of Dermatology and Venereology.

Journal of the European Academy of Dermatology and Venereology

2022

Data from this systematic review strongly suggest the association of asthma with periodontal disease.

Journal of Periodontology

2018

Oral health problems may have numerous effects on general health, including physical fitness and performance. In this review, we aimed to systematically review the available evidence to assess the effect of oral health on general physical fitness.

Heliyon

2020

In this cohort, periodontal diseases appeared to be associated with an increased risk of developing cardiovascular, cardiometabolic, autoimmune diseases and mental ill health.

BMJ Open

2022

Oral health may be impaired in these patients related to the disease itself, due to cytopenia, or related to the drugs the patients use, such as glucocorticoids.

Pediatric Dental Journal

2022

Oral manifestations may precede gastrointestinal symptoms. Patients presenting such manifestations should be screened for coeliac disease. The cooperation of gastroenterologists and dentists could lead to an increased detectability of coeliac disease.

Journal of Pediatrics and Child Health

2023

(Saudi) children with Celiac Disease had a greater number of clinical findings of recurrent aphthous stomatitis (RAS) and dental enamel defects (DEDs) than healthy controls.

BMC

2022

In this retrospective explorative pilot study, alveolar bone loss and tooth loss are associated with the severity of COVID-19, however they are not independent risk factors.

Advances in Oral and Maxillofacial Surgery

2021

Poor occlusal support status was significantly associated with Erectile Dysfunction (ED) in community-dwelling men, as opposed to remaining teeth number and periodontal health status.

International Journal of Urology

2024

The purpose of our study was to explore further the association between chronic periodontitis and glaucoma in a retrospective case-control study design.

Investigative Ophthalmology and Visual Disease

2022

Dental diagnoses within 12 months of Total hip arthroplasty (THA) are associated with increased medical complications. Dental diagnoses occurring 12 months after THA are associated with greater implant-related complications, including periprosthetic joint infections (PJIs). Delaying invasive dental procedures for 12 months after THA may be advisable.

The Journal of Athroplasty

2024

Postmenopausal women with HIV have deterioration of the alveolar trabecular bone microarchitecture that may contribute to greater tooth loss.

BMC Oral Health

2024

Patients with hemophilia have an increased risk of developing dental caries.

European Journal of Dentistry

2022

Combined symptom and microbiome evaluation may help in the early detection of pancreatic cancer.

World J Gastroenterol.

2020

Lack of dental care during inpatient stays may be responsible for hundreds of thousands of hospital-acquired infections each year, including nonventilator hospital-acquired pneumonia, which can be fatal in up to 30% of infected patients, especially those lying flat or staying immobile for long periods of time. A greater focus on brushing patients' teeth regularly during hospital stays is needed, some experts say.

Kaiser Health News

2022

The present review indicated that too little sleep duration (≤5 hours) significantly increased the risk of periodontitis. However, the evidence is limited due to cross-sectional design of most studies, hence longitudinal studies should be conducted to support this finding.

International Dental Journal

2024

According to the results, periodontitis has been shown to be associated with mild-to-moderate obstructive sleep apnea (OSA), but not with severe OSA.

Journal of Clinical and Experimental Dentistry

2022

This study of Sjogren’s Disease patients diagnosed in community practices characterized three different Sjogren’s Disease clinical presentations, which can be used to generate Sjogren’s Disease study cohorts for longitudinal studies using electronic health record data.

Plos One

2023