Parkinson’s Disease
These findings identify microbial imidazole propionate (ImP), produced via the enzyme urocanate reductase (UrdA), as a direct pathological mediator of the gut-brain axis in Parkinson’s Disease (PD).
Nature Communications
2025
Our findings highlight the significance of the oral-gut-brain axis and underscore its potential for discovering novel biomarkers for Parkinson’s Disease (PD) and Cognitive impairment (CI).
Gut Microbiomes
2025
We found 501 CpG sites and 24 genes as candidate biomarkers, as well as 56 expression Quantitative Trait Methylation (eQTMs) linked to conditions such as prostate cancer, squamous cell carcinoma, coronary artery disease, type 2 diabetes, and Parkinson’s disease.
npj Genomic Medicine
2025