Additional Connections
Abscesses
Association of periodontal disease and the prevalence of acute periapical abscesses
Under the conditions of this study, it appears that the odds for acute periapical abscesses (PAs) are significantly higher in patients with periodontal disease (PD) seeking treatment for pain due to acute PAs.
Journal of the American Dental Association
2025
ADHD
The findings of this study suggest a significant association between attention deficit hyperactivity disorder (ADHD) and an increased risk of traumatic dental injuries (TDIs). Individuals with ADHD were found to be nearly 2x as likely to experience TDIs compared to those without ADHD.
European Review for Medical and Pharmacological Studies
2024
Alopecia
Periodontitis and risk of alopecia areata: A nationwide population-based cohort study in Korea
Patients with periodontitis may be at a much greater risk of developing alopecia areata, an autoimmune disease characterized by hair loss, according to a study published on November 17 in the Journal of the European Academy of Dermatology and Venereology.
Journal of the European Academy of Dermatology and Venereology
2022
Antibiotics
While the timing of antibiotic administration relative to scaling and root planing (SRP) did not influence the overall clinical efficacy of periodontal treatment, initiating antibiotics on the first day of mechanical debridement promoted a more rapid and beneficial restructuring of the subgingival microbial community.
Journal of Periodontology
2026
Asthma
Inhaled anti-asthmatic therapy and tooth wear in children and adolescents: a case-control study
Conclusions Inhaled asthma therapy—especially with dry powder inhalers (DPIs) and combination regimens—is associated with increased tooth wear. Emphasizing mouth rinsing after inhaler use and preventive dental care may reduce the risk in pediatric asthma patients.
Scientific Reports
2025
Asthmatic children should avoid drinking acidic drinks since longer duration of asthma medication use is already associating them with higher erosive tooth wear (ETW) presence. From the ETW point of view, metered-dose inhaled medications are more tooth-friendly than dry powder inhaled forms.
Clinical and Experimental Dental Research
2025
Association between asthma and periodontal disease: A systematic review and meta-analysis
Data from this systematic review strongly suggest the association of asthma with periodontal disease.
Journal of Periodontology
2018
Athletics
The impact of oral health on physical fitness: A systematic review
Oral health problems may have numerous effects on general health, including physical fitness and performance. In this review, we aimed to systematically review the available evidence to assess the effect of oral health on general physical fitness.
Heliyon
2020
Autism
Auto-immune
Self-reported oral health issues were associated with an increased risk of incident autoimmune diseases, suggesting that oral health indicators may serve as clinically relevant markers of autoimmune disease risk.
BMC Oral Health
2026
In this cohort, periodontal diseases appeared to be associated with an increased risk of developing cardiovascular, cardiometabolic, autoimmune diseases and mental ill health.
BMJ Open
2022
Birth Control Medication
The use of oral contraceptives (OCs) has been demonstrated to enhance the likelihood of encountering self-reported headaches and increased tenderness to palpation within the masticatory system in female adolescents. Consequently, the utilization of OC in female adolescents with temporomandibular disorders warrants further consideration.
Journal of Oral Rehabilitation
2026
Blood Disorders
Dental caries was more prevalent among anemic children compared to non-anemic ones with a low level of certainty.
Journal of Human Nutrition and Dietetics
2025
Bone Density
New insights into the correlation between bone mineral density and dental caries in NHANES 2011-2016
Monitoring bone mineral density (BMD) should be combined with appropriate oral healthcare and caries management strategies to effectively address these interconnected health issues, and particular attention should be paid to the monitoring of head BMD.
Scientific Reports
2024
Bone Marrow Disease
Oral health status of patients with inherited bone marrow failure syndromes
Oral health may be impaired in these patients related to the disease itself, due to cytopenia, or related to the drugs the patients use, such as glucocorticoids.
Pediatric Dental Journal
2022
Brain
Older adults with self-reported psychiatric diseases, females, and those without dental access exhibited higher rates of tooth loss. Public policies should aim to integrate mental and oral health, ensuring equitable access to dental care for these most vulnerable groups.
Special Care in Dentistry
2026
We examined how early life exposures to mixtures of metals affect children’s brain and behavior using naturally shed “baby” teeth as a biomarker of direct exposure. Findings suggest that the developing brain is especially vulnerable to metals in early life, with lasting effects into adolescence.
Science Advances
2026
The present study revealed that the impact of tooth loss on cognitive decline was not dependent on the low-protein diet condition.
Archives in Oral Biology
2026
Periodontal disease (PD) was independently associated with greater white matter hyperintensities (WMHs) burden, a key imaging marker of cerebral small vessel disease (CSVD), but not with cerebral microbleeds (CMBs) or lacunar infarcts after adjustment for confounders. This suggests that PD may contribute to CSVD pathology, particularly WMHs, through mechanisms involving systemic inflammation. Limitations include the temporal gap between dental and imaging assessments and potential residual confounding. Interventions targeting PD could be explored as a modifiable risk factor for CSVD prevention.
Neurology Open Access
2025
Our findings highlight the significance of the oral-gut-brain axis and underscore its potential for discovering novel biomarkers for Parkinson’s Disease (PD) and cognitive impairment (CI).
Gut Microbiomes
2025
Poor periodontal health may increase the risk of cognitive decline. Future studies into the underlying mechanisms are warranted.
Journal of Clinical Periodontology
2025
Celiac Disease
Celiac disease and its implications on the oral health of children: A systematic review
Oral manifestations may precede gastrointestinal symptoms. Patients presenting such manifestations should be screened for coeliac disease. The cooperation of gastroenterologists and dentists could lead to an increased detectability of coeliac disease.
Journal of Pediatrics and Child Health
2023
Oral and dental manifestations of celiac disease in children: a case-control study
(Saudi) children with Celiac Disease had a greater number of clinical findings of recurrent aphthous stomatitis (RAS) and dental enamel defects (DEDs) than healthy controls.
BMC
2022
Climate Change
COVID
In this retrospective explorative pilot study, alveolar bone loss and tooth loss are associated with the severity of COVID-19, however they are not independent risk factors.
Advances in Oral and Maxillofacial Surgery
2021
Epilepsy
This study underscores the effect of oral microbiota (OM) on epilepsy, suggesting potential mechanisms between the OM and epilepsy. Further investigation into the potential role of the OM is needed to enhance our in-depth understanding of the pathogenesis of epilepsy.
Epilepsia Open
2024
Erectile Dysfunction
Periodontitis is strongly associated with severe ED (SED) treated with penile prostheses, linked to lower endothelial nitric oxide synthase (eNOS) expression in penile tissue. Diabetes and age were identified as additional independent risk factors for SED.
Journal of Periodontology
2025
Poor occlusal support status was significantly associated with Erectile Dysfunction (ED) in community-dwelling men, as opposed to remaining teeth number and periodontal health status.
International Journal of Urology
2024
Eye health
Association between poor oral health and risk of glaucoma
Article:
Eye spy: Exploring the mouth-eye connection (EXCELLENT FOOTNOTES)
The purpose of our study was to explore further the association between chronic periodontitis and glaucoma in a retrospective case-control study design.
Investigative Ophthalmology and Visual Disease
2022
Gastrointestinal Conditions
Based on literature and meta-analyzes with few studies, evidence suggests that individuals with gastroesophageal reflux disease (GERD) and peptic ulcers were more likely to have periodontal disease and caries compared to individuals without these conditions.
Journal of Evidence-Based Dental Practice
2026
Ulcerative colitis (UC) and Crohn’s disease (CD) patients were more likely to develop periodontitis, with low heterogeneity between studies, while the prevalence of periodontitis among UC and CD patients was not meaningfully different.
BMC Oral Health
2025
Periodontitis may augment the risk of incidence for Crohn’s disease (CD) and ulcerative colitis (UC). This association underscores the potential significance of periodontal health in the context of IBD, emphasizing the importance of comprehensive oral hygiene practices and potential preventive strategies to reduce the risk of CD and UC incidence.
The American Journal of Gastroenterology
2025
Dysbiosis of the saliva microbiota is linked to various upper gastrointestinal (UGI) disorders. However, microbiota dysbiosis in subgingival and buccal mucosa sites are specifically associated with the pre-malignant conditions Barrett’s esophagus and gastric atrophy. The oral microbiome, particularly in the subgingival location, might act as biomarkers for UGI cancers.
The American Journal of Gastroenterology
2024
Based on limited longitudinal evidence, patients with periodontitis do not exhibit an increased risk of developing IBD overall, but they are at increased risk of ulcerative colitis (UC); not Crohn’s disease (CD).
Journal of Periodontal Research
2024
Periodontitis Prevalence and Severity in Inflammatory Bowel Disease: A Case-Control Study
Relevant associations between inflammatory bowel disease (IBD) and periodontitis were found, being modified by Crohn’s disease (CD) and ulcerative colitis (UC) clinical characteristics.
Journal of Periodontology
2022
Gut Health
Oral microbiota shifts following tooth loss affect gut health
In the mouse model, tooth loss disrupted the balance of the oral-gut microbiota, with potential implications for intestinal health. Although these findings are from a murine model, considering the existence of the oral-gut axis balance in the human body, it is reasonable to postulate that following tooth loss in humans, the health of the intestinal microecology may also warrant attention.
BMC Oral Health
2025
Hemophilia
The use of prophylactic clotting factors during dental interventions in hemophilia patients showed notable inconsistencies across studies. This inconsistency underscores the importance of conducting larger, prospective clinical studies to better understand the rationale behind clotting factor use and its effects on dental treatment outcomes in patients with varying degrees of hemophilia severity.
BMC Oral Health
2026
Assessment of Oral Health and Healthy Habits in Adult Patients with Congenital Hemophilia
Patients with hemophilia have an increased risk of developing dental caries.
European Journal of Dentistry
2022
Hip Replacement
Dental diagnoses within 12 months of Total hip arthroplasty (THA) are associated with increased medical complications. Dental diagnoses occurring 12 months after THA are associated with greater implant-related complications, including periprosthetic joint infections (PJIs). Delaying invasive dental procedures for 12 months after THA may be advisable.
The Journal of Athroplasty
2024
HIV
Postmenopausal women with HIV have increased tooth loss
Postmenopausal women with HIV have deterioration of the alveolar trabecular bone microarchitecture that may contribute to greater tooth loss.
BMC Oral Health
2024
Human Papillomavirus (HPV)
Oral human papillomavirus (HPV) infection, especially with high-risk HPV, is significantly associated with OL. Further prospective trials are encouraged to validate these results and elucidate the exact role of HPV in oral leukoplakia (OL).
International Dental Journal
2025
Human papillomavirus (HPV) infection and cervical cancer (CC) impact both the vaginal and oral microenvironments, affecting systemic metabolism and the synergy between bacteria. This suggests that the use of oral flora markers is a potential screening tool for the diagnosis of CC.
Journal of Translational Medicine
2024
Infertility
This review highlights the systemic implications of periodontal disease on male reproductive health. Given the global decline in male fertility, maintaining oral health may serve as an adjunct strategy in managing infertility. Future research should prioritize large-scale, longitudinal studies to establish causality and explore preventive interventions.
BMC Oral Health
2025
Liver Function
An increased count of fixed prostheses is associated with changes in liver function markers in a gender-dependent manner, with blood lead levels serving as a potential mediator in males.
Environmental Pollution
2024
Lupus
Dental decay and the fungal and bacterial flora of supragingival dental plaque patients are higher than in the healthy group. It is recommended that these patients pay more attention to their oral hygiene and undergo periodic oral examinations.
BMC Oral Health 2025
Medication
Radiomics analysis of pretreatment multidetector row computed tomography (MDCT) images may accurately predict
Oral Diseases – Leading in Oral,
2026
Effect of different medications on implant complications and success rate: A retrospective study
Self-reported and prescribed medications were associated with adverse implant outcomes. Antidepressants, opioids, and oral bisphosphonates were linked to peri-implant and mechanical complications, whereas antibiotic exposure and the use of chlorhexidine gluconate were associated with reduced soft tissue complications.
The Journal of Prosthetic Dentistry
2026
Neurological Disorders
Association Between Migraine and Periodontitis: A Systematic Review and Meta-Analysis
Through this meta-analysis, we have seen how there is a statistically significant relationship between periodontitis and migraine.
European Journal of Neurology
2025
The higher prevalence of Idiopathic intracranial hypertension (IIH) signs on neuroimaging (empty sella, enlargement of the optic nerve sheets and dural sinus stenosis) in burning mouth syndrome (BMS) patients compared to HCs highlights that BMS should be considered a chronic neurological disorder.
Journal of Oral Rehabilitation
2025
Through this meta-analysis, we have seen how there is a statistically significant relationship between periodontitis and migraine.
European Journal of Neurology
2025
Oral Microbiome
Oral microbiome and pancreatic cancer
Combined symptom and microbiome evaluation may help in the early detection of pancreatic cancer.
World J Gastroenterol.
2020
Pneumonia
This multicentre randomised controlled trial demonstrates that improving oral care reduces non-ventilator hospital-acquired pneumonia (NV-HAP) incidence among hospitalised patients, compared with usual care. Our findings provide novel and clinically important evidence to inform future prevention guidelines and hospital infection control policy.
The Lancet Infectious Diseases
2026
Implementing structured oral care at least 2 weeks before surgery reduced postoperative pneumonia and shortened hospital stays across various surgical procedures, suggesting its value as a preventive strategy for improving surgical outcomes.
Plos One
2025
The findings of this systematic review and meta-analysis suggest that daily toothbrushing may be associated with significantly lower rates of Hospital-acquired pneumonia (HAP), particularly in patients receiving mechanical ventilation, lower rates of ICU mortality, shorter duration of mechanical ventilation, and shorter ICU length of stay. Policies and programs encouraging more widespread and consistent toothbrushing are warranted.
JAMA Internal Medicine
2023
Within the limitations of this study, our evidence supports the role of denture acrylic biomaterials as a potential colonization site for putative respiratory pathogens, which may lead to an increased risk of pneumonia in susceptible individuals. These findings support prior observational studies which have found denture-wearers to be at increased risk of respiratory infection. Further research is needed to confirm the sequence of colonization and translocation to examine potential causal relationships.
Journal of Medical Microbiology
2023
Oral health status of patients with inherited bone marrow failure syndromes
Article:
Hospital-Acquired Pneumonia Is Killing Patients. Yet There Is a Simple Way to Stop It.
Lack of dental care during inpatient stays may be responsible for hundreds of thousands of hospital-acquired infections each year, including nonventilator hospital-acquired pneumonia, which can be fatal in up to 30% of infected patients, especially those lying flat or staying immobile for long periods of time. A greater focus on brushing patients’ teeth regularly during hospital stays is needed, some experts say.
Kaiser Health News
2022
PTSD
Exploring post-traumatic stress among patients at a clinic for orofacial pain and dysfunction
The presence of PTSD in this clinical sample was associated with the presence of painful TMD and awake bruxism. The presence of a reported potentially traumatic event without PTSD was not associated with painful TMD or awake bruxism. Finally, when examining symptom severity, the severity of awake bruxism was correlated to post-traumatic stress symptoms.
Journal of Dentistry
2025
Sarcopenia
Edentulism is a robust, independent marker of elevated sarcopenia risk in Chinese adults, with particularly strong effects in socio-economically vulnerable subgroups. Routine oral-health screening should be integrated into geriatric assessments to identify patients at high risk for sarcopenia.
BMC Oral Health
2025
Exploring post-traumatic stress among patients at a clinic for orofacial pain and dysfunction
The presence of PTSD in this clinical sample was associated with the presence of painful TMD and awake bruxism. The presence of a reported potentially traumatic event without PTSD was not associated with painful TMD or awake bruxism. Finally, when examining symptom severity, the severity of awake bruxism was correlated to post-traumatic stress symptoms.
Journal of Dentistry
2025
Sickle Cell Anemia
Sickle Cell Disease and Dental Care Access Among Medicaid-Enrolled Youths (Supporting article:
Spinal Pain
Spinal pain in preadolescence was associated with significantly higher odds of painful temporomandibular disorders (p-TMD)and headache in young adulthood. These findings suggest that preadolescent spinal pain may represent an early marker of vulnerability to p-TMD and headache in young adulthood.
The Journal of Pain
2026
Sjogren’s Syndrome
This study of Sjogren’s Disease patients diagnosed in community practices characterized three different Sjogren’s Disease clinical presentations, which can be used to generate Sjogren’s Disease study cohorts for longitudinal studies using electronic health record data.
Plos One
2023
Transplants
Impact of Dental Status on Heart Transplantation Outcomes
Poor dental health was not directly associated with post-transplant mortality but was linked to a higher sepsis risk, which negatively affected outcomes.
Oral Diseases
2025
Vaccines
This study demonstrates a statistically significant but modestly increased risk of oral lichen planus (OLP) and oral lichenoid lesions (OLL) following hepatitis B vaccination. Given the small effect size and observational design, the findings should be interpreted as hypothesis-generating.
BMC Oral Health
2025