Osteoporosis
This review examines the epidemiological evidence and shares mechanistic pathways that establish a bidirectional relationship between systemic skeletal bone loss and localized alveolar bone destruction. Our review found abundant clinical evidence that osteoporosis is linked to a notably higher risk of severe periodontitis, likely due to estrogen deficiency affecting bone metabolism. Clinical data on how periodontitis impacts the prevalence and progression of osteoporosis remain limited, although some studies suggest an association between periodontitis and osteoporosis, especially in postmenopausal women.
Journal of Periodontal Research
2026
Our data demonstrate that periodontitis can affect systemic bone metabolism via the oral–gut axis and that tryptophan metabolite indole-3-lactic acid (ILA) supplementation serves as a potential therapeutic option to mitigate these adverse effects.
International Journal of Oral Science
2026
From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture
Dental caries causally increases the risk of osteoporosis (OP) and postmenopausal OP with pathological fracture, suggesting the existence of teeth-bone axis. Proactive osteoporosis screening in patients with severe dental caries may be warranted for clinical consideration.
BMC Oral Health
2025
Relationship between bone mineral density and oral health: a cross sectional observational study
Tooth loss and dental decay rates were significantly high in patients with osteoporosis. Although bone resorption during osteopenia is not excessive, it constitutes a crucial risk factor for dental health.
BMC Oral Health
2025
The Association between Bone Mineral Density and Periodontal Disease in Middle-Aged Adults
Low bone mass was associated with the risk of Periodontal Disease among young adults
International Journal of Environmental Research and Public Health
2021
Are radiographic changes in the mandibular canal associated with bone mineral density?
Our findings demonstrate an association between bone mineral density (BMD) assessed in the mandibular canal cortex and the presence of osteoporosis as determined by dual-energy x-ray absorptiometry (DXA).
Journal of Oral and Maxillofacial Surgery
2024
Oral implications of osteoporosis
Evidence from (97) prospective studies supports the contention that individuals with osteoporosis may be at increased risk for the manifestations of oral osteoporosis; however, such risk is not definitively proven.
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
2005