Cardiovascular Disease
Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches
In this review, we summarized clinical findings on the association between periodontitis and thrombotic diseases and discussed several novel prothrombotic periodontitis-related agents, and presented a perspective to emphasize the necessity of oral health management for people at high risk of thrombosis.
International Journal of Oral Science
2024
Oral health behavior associated with cardiometabolic outcomes: A nationally representative cross-sectional study in Portugal
Individuals with poor oral health behavior had a higher prevalence of diabetes and high/very high cardiovascular risk. Sensitivity analysis suggested that regular tooth brushing may be the main behavior for preventing diabetes and cardiovascular risk. The results suggest that regular tooth brushing may act in prevention for diabetes and cardiovascular risk.
International Journal of Cardiology
2025
| Regular dental flossing may lower risk of stroke from blood clots, irregular heartbeats |
- People who regularly floss their teeth (1+ times per week) may lower their risk of stroke caused by a blood clot traveling from the heart and a stroke associated with an irregular heartbeat such as atrial fibrillation (AFib).
- The benefits of regular flossing may be independent of tooth brushing and other oral hygiene behaviors.
- Researchers suggest that flossing is a healthy habit that is affordable, easy to adopt and accessible everywhere.
| American Stroke Association International Stroke Conference 2025 – Abstract 19 |
2025
| A common mouth and gut bacteria may be linked with increased stroke risk |
- Increased levels of Streptococcus anginosus, a common type of bacteria that usually lives in the mouth and gut, was found in the gut of recent stroke survivors in Japan.
- Over two years, stroke patients with a significant amount of Streptococcus anginosus bacteria in their gut were more likely to die or have another major cardiovascular event than stroke patients without Streptococcus anginosus in the gut.
- The results suggest that analyzing mouth and gut bacteria may someday help determine stroke risk, and that targeting these harmful bacteria with new therapies and proper dental hygiene may help prevent stroke.
| American Stroke Association International Stroke Conference 2025 – Abstract 106 |
2025
| The qualitative positivity for Fusobacterium nucleatum in the oral cavity was independently associated with high-grade white matter hyperintensities and high-grade total cerebral small vessel disease (CSVD) score in patients with ischemic stroke. Thus, oral care targeting Fusobacterium nucleatum may aid in impeding CSVD progression. |
| Journal of Stroke and Cerebrovascular Diseases |
2024
The present systematic review reported that being edentulous or having lesser than 10 teeth is a predictive indicator of Cardiovascular Disease (CVD) mortality.
| Journal of Endodontics |
2024
Insulin resistance and periodontitis: Mediation by blood pressure
The triglyceride-glucose (TyG) index was associated with increased odds of moderate / severe periodontitis, especially in individuals with obesity, hypertension, and dyslipidemia. Systolic blood pressure (SBP) levels partially mediated this association.
| Journal of Periodontal Research |
2024
Our findings indicate that there is no genetic causal association between periodontitis and infective endocarditis.
International Dental Journal
2024
Impaired oral status is associated with sarcopenic obesity in post-stroke patients
Oral problems were associated with sarcopenic obesity in post-stroke. Oral assessment and intervention may have a positive impact on Activities of Daily Living (ADL) and Quality of Life (QOL) in post-stroke patients with sarcopenic obesity.
Wiley
2024
Periodontitis, Dental Procedures, and Young-Onset Cryptogenic Stroke
Periodontitis and recent invasive dental procedures were associated with Cryptogenic Ischemic Stroke (CIS) after controlling for multiple confounders.
Sage Journals
2024
Periodontitis aggravates COPD through the activation of γδ T cell and M2 macrophage
Results identified the crucial role of γδ T-M2 immune mechanism in mediating periodontitis-promoted COPD progression.
mSystems
2024
Presence of decayed, filled, missing teeth linked to stroke risk
- Having decayed, filled and/or missing teeth was tied to increased risk for stroke and death.
- Risk was especially high among Black individuals compared with white individuals.
Helio
2023
Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
Specific oral bacteria are associated with baseline blood pressure status and risk of hypertension development among postmenopausal women. Research to confirm these observations and elucidate mechanisms is needed.
Journal of the American Heart Association
2023
Oral inflammatory load predicts vascular function in a young adult population: a pilot study
We found that whole mouth oral inflammatory load was a predictor of reduced flow-mediated dilation. An impairment in flow-mediated dilation is an indicator of future possible risk of cardiovascular disease-one of the leading causes of death in North America.
Frontiers
2023
The authors histologically revealed the association of periodontitis with atrial fibrosis. This indicates that periodontitis, which is modifiable, is likely a risk factor for atrial fibrillation.
Journals of the American College of Cardiology
2022
Periodontal Status, C-Reactive Protein, NT-proBNP, and Incident Heart Failure: The ARIC Study
Periodontal status was associated with incident heart failure, heart failure with preserved ejection fraction, and heart failure with reduced ejection fraction, as well as unfavorable changes in C-reactive protein and congestion.
JACC: Heart Failure
2022
Preventive dental care is strongly associated with significant savings for diabetes and CAD patients, and such savings were highest for diabetes + CAD patients, followed by patients with only CAD and only diabetes.
Compendium of Continuing Education in Dentistry
2022
Association between periodontal care and hospitalization with acute myocardial infarction
We found that periodontal care was associated with more after acute myocardial infarction (AMI) visits. This suggests that there is a benefit to incorporating oral health care and medical care to improve AMI outcomes.
Journal of the American Dental Association
2022
ARTICLE: Periodontal disease diagnosis tied to CVD risk
Adults with a recorded diagnosis of a periodontal disease, including gingivitis and periodontitis, are more likely to develop CVD and other chronic diseases compared with patients without a diagnosis.
Healio
2022
Oral Microbiome Is Associated With Incident Hypertension Among Postmenopausal Women
Study concluded that specific oral bacteria are associated with baseline blood pressure status and risk of hypertension development among postmenopausal women.
Journal of the American Heart Association
2022
Frequent tooth brushing was associated with reduced risks of incident hypertension and T2DM. Tooth brushing at least twice a day may prevent future hypertension and T2DM events.
Journal of Hypertension
2022
ARTICLE: Intensive Dental Care on Shaky Footing for Cardiovascular Prevention
Intensive gum disease treatment failed as a measure of secondary prevention for stroke survivors in the “stroke belt” of the U.S., a randomized study found.
PREMIERS
2022
This study aimed to evaluate the causal association of periodontal disease with acute myocardial infarction (AMI) and stroke, after controlling for various confounders among the Korean population. Our data confirmed that severe periodontal disease was causally associated with the new events of AMI and stroke.
Journal of Dental Research
2021
Pre-cardiac dental treatment does not increase the risk of adverse events
The results of this study suggest that elimination of oral infection prior to cardiovascular surgery does not increase the risk of morbidity or mortality.
Journal of Oral and Maxillofacial Surgery
2021
Other articles:
AHA News: How Oral Health May Affect Your Heart, Brain and Risk of Death
Dental cavities can raise risk of heart disease, stroke, according to scientists
Streptococcal bacteria, mostly of oral origin, may contribute to the progression and thrombotic events of cerebrovascular diseases.
Journal of the American Heart Association
2021
Periodontal Disease, Atrial Fibrillation and Stroke
Those who kept up with routine dental care had lower risks of atrial fibrillation than those who only went to the dentist when they experienced discomfort or needed dental work or who failed to keep a regular appointment schedule
American Heart Journal
2021
Association Between Periodontitis and Blood Pressure Highlighted in Systemically Healthy Individuals
Study aimed to investigate the relationship between periodontitis and mean arterial blood pressure in a sample of otherwise systemically healthy individuals.
Hypertension
2021
Rheumatoid arthritis (RA) patients have elevated rates of perio and cardiovascular disease, suggesting that their immune responses to gum disease bacteria may be linked to higher heart disease risk.
Arthritis and Rheumatology
2020
Abstract P441: Dental Caries a Risk Factor for Intracerebral Hemorrhage
Reports a significant association between dental caries and intracerebral hemorrhage (ICH).
Stroke
2020
Provides consistent and strong epidemiologic evidence that periodontitis increased risk for future cardiovascular disease
Journal of Clinical Periodontology
2013