Cancer
Oral Microbiome and Subsequent Risk of Head and Neck Squamous Cell Cancer
This case-control study yielded compelling evidence that oral bacteria are a risk factor for head and neck squamous cell cancer (HNSCC) development. The identified bacteria and bacterial complexes hold promise, along with other risk factors, to identify high-risk individuals for personalized prevention of HNSCC.
Journal of the American Medical Association (JAMA)
2024
Long-Term Survival of Dental Implants in Irradiated Patients
For patients with head and neck cancer (HNC), implants in the irradiated upper jaw may have lower survival rates than those placed in the lower jaw.
Oral and Maxillofacial Surgery Clinics of North America
2024
| Systematic analyses uncover robust salivary microbial signatures and host-microbiome perturbations in oral squamous cell carcinoma |
| Collectively, our findings uncovered complex alterations in the oral microbiome in Oral Squamous Cell Carcinoma (OSCC), providing novel insights into disease etiology and paving the way for microbiome-based diagnostic and therapeutic strategies. |
| American Society for Microbiology Journal |
2025
Periodontitis and dental quality of life predict long-term survival in head and neck cancer
The degree of alveolar bone loss, as determined by orthopantomogram (OPG), and dental health-related quality of life (HRQoL) both obtained at the time of head and neck squamous cell carcinoma (HNSCC) diagnosis, predicted long-term survival. When analyzed simultaneously, both factors remained significant in both univariate and multivariate analyses, adjusted by pertinent clinical variables, highlighting their unique prognostic value.
| BMC Oral Health |
2024
ARTICLE: Simple “swish-and-spit” oral rinse could provide early screening for gastric cancer
A simple oral rinse could provide early detection of gastric cancer, the fourth-leading cause of cancer deaths worldwide, according to a study scheduled for presentation at Digestive Disease Week® 2024.
Press Release
2024
Human papillomavirus (HPV) infection and cervical cancer (CC) impact both the vaginal and oral microenvironments, affecting systemic metabolism and the synergy between bacteria. This suggests that the use of oral flora markers is a potential screening tool for the diagnosis of CC.
Journal of Translational Medicine
2024
A distinct Fusobacterium nucleatum clade dominates the colorectal cancer niche
Our results identify the Fna clade bifurcation, show that specifically Fna C2 drives the reported Fn enrichment in human colorectal cancer (CRC), and reveal the genetic underpinnings of pathoadaptation of Fna C2 to the CRC niche
Nature
2024
The Ca2+ channel ORAI1 is a regulator of oral cancer growth and nociceptive pain
We report here that the function of the Ca2+ channel ORAI1 is an important regulator of oral cancer pain.
Science Signaling
2023
Mouth pathogens may trigger oral squamous cell carcinoma
Evaluates the impact of periodontal disease on the development of oral cancer
PLOS Pathogen
2020
Periodontal Disease, Tooth Loss, and Risk of Serrated Polyps and Conventional Adenomas
Concludes that a history of perio disease and possibly higher number of tooth loss may modestly increase the risk of developing colorectal precursor lesions.
American Association for Cancer Research
2020
Certain oral bacteria linked to higher risk for esophageal cancer
Oral bacteria appeared to be more abundant in patients with esophageal cancer compared with otherwise healthy controls
Cancer (American Cancer Society)
2020
Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study
Provides additional evidence that cancer risk, especially for lung and colorectal cancer, is elevated in individuals with perio disease.
Journal of the National Cancer Institute
2018
Periodontal Treatment in Cancer Patients: An Interdisciplinary Approach
Provides a review of the literature to determine the relationships between dental care in the cancer patient to provide strategic suggestions.
NIH — US Library of Medicine
2018
Reviews appropriate care strategies (perio maintenance, extractions) before and after head and neck cancer treatment and strategies to prevent osteoradionecrosis.
NIH — US Library of Medicine
2018
Study findings support the need for further understanding of the effect of periodontal disease on cancer outcomes
Cancer Epidemiology, Biomarkers & Prevention
2017
Relevant Articles:
Researchers Examine The “Oral Microbiome” To Look For Clues To Cancer Risk.
Study: Women With Periodontal Disease Had Higher Risk Of Several Cancer Types.