Additional Connections
Liver function
An increased count of fixed prostheses is associated with changes in liver function markers in a gender-dependent manner, with blood lead levels serving as a potential mediator in males.
Environmental Pollution
2024
Sleep
Bidirectional Relationship Between Dental Diseases and Sleep Disturbances in Pediatric Patients
Evidence provided by previous studies has indicated that common dental diseases, including dental caries, temporomandibular disorders, and dentofacial deformities, induced sleep disturbances in children and adolescents. On the other hand, common sleep disturbances such as sleep disordered breathing, obstructive sleep apnea, as well as other sleep problems, including sleep bruxism and sleep profile impairments, have a strong link to oral health conditions in pediatric patients. Alteration of oral microorganism colonization, impairment in the immune system, persistent inflammation, and chronic pain have contributed to sleep disorders triggered by these dental diseases.
Clinical and Experimental Dental Research
2025
Long-term mandibular advancement appliance therapy for obstructive sleep apnea
Results of long-term mandibular advancement appliance (MAA) therapy for obstructive sleep apnea (OSA), with more than a decade of use, showed significant benefits in improving self-perception of OSA symptoms, reducing daytime sleepiness, and enhancing partner satisfaction.
Journal of the American Dental Association
2025
Findings suggest a significant association between dentofacial characteristics and sleep quality in young adults. Protruding facial profiles and anterior crossbites were identified as independent predictors for sleep disorders (SDs). These findings underscore the importance of screening for SDs in individuals with dentofacial deformities and highlight the potential benefits of early correction of such dentofacial abnormalities to reduce the risk of SDs in adulthood.
BMC Oral Health
2025
Findings suggest a significant association between dentofacial characteristics and sleep quality in young adults. Protruding facial profiles and anterior crossbites were identified as independent predictors for sleep disorders (SDs). These findings underscore the importance of screening for SDs in individuals with dentofacial deformities and highlight the potential benefits of early correction of such dentofacial abnormalities to reduce the risk of SDs in adulthood.
BMC Oral Health
2025
Gut Health
Oral microbiota shifts following tooth loss affect gut health
In the mouse model, tooth loss disrupted the balance of the oral-gut microbiota, with potential implications for intestinal health. Although these findings are from a murine model, considering the existence of the oral-gut axis balance in the human body, it is reasonable to postulate that following tooth loss in humans, the health of the intestinal microecology may also warrant attention.
BMC Oral Health
2025
Abscesses
Association of periodontal disease and the prevalence of acute periapical abscesses
Under the conditions of this study, it appears that the odds for acute periapical abscesses (PAs) are significantly higher in patients with periodontal disease (PD) seeking treatment for pain due to acute PAs.
Journal of the American Dental Association
2025
Epilepsy
This study underscores the effect of oral microbiota (OM) on epilepsy, suggesting potential mechanisms between the OM and epilepsy. Further investigation into the potential role of the OM is needed to enhance our in-depth understanding of the pathogenesis of epilepsy.
Epilepsia Open
2024
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Bone density New insights into the correlation between bone mineral density and dental caries in NHANES 2011-2016 |
| Monitoring bone mineral density (BMD) should be combined with appropriate oral healthcare and caries management strategies to effectively address these interconnected health issues, and particular attention should be paid to the monitoring of head BMD. |
| Scientific Reports |
2024
ADHD
The findings of this study suggest a significant association between attention deficit hyperactivity disorder (ADHD) and an increased risk of traumatic dental injuries (TDIs). Individuals with ADHD were found to be nearly 2x as likely to experience TDIs compared to those without ADHD.
European Review for Medical and Pharmacological Studies
2024
Alopecia
Periodontitis and risk of alopecia areata: A nationwide population-based cohort study in Korea
Patients with periodontitis may be at a much greater risk of developing alopecia areata, an autoimmune disease characterized by hair loss, according to a study published on November 17 in the Journal of the European Academy of Dermatology and Venereology.
Journal of the European Academy of Dermatology and Venereology
2022
Asthma
Association between asthma and periodontal disease: A systematic review and meta-analysis
Data from this systematic review strongly suggest the association of asthma with periodontal disease.
Journal of Periodontology
2018
Athletics
The impact of oral health on physical fitness: A systematic review
Oral health problems may have numerous effects on general health, including physical fitness and performance. In this review, we aimed to systematically review the available evidence to assess the effect of oral health on general physical fitness.
Heliyon
2020
Autism
Auto-immune
In this cohort, periodontal diseases appeared to be associated with an increased risk of developing cardiovascular, cardiometabolic, autoimmune diseases and mental ill health.
BMJ Open
2022
Bone marrow disease
Oral health status of patients with inherited bone marrow failure syndromes
Oral health may be impaired in these patients related to the disease itself, due to cytopenia, or related to the drugs the patients use, such as glucocorticoids.
Pediatric Dental Journal
2022
Celiac Disease
Celiac disease and its implications on the oral health of children: A systematic review
Oral manifestations may precede gastrointestinal symptoms. Patients presenting such manifestations should be screened for coeliac disease. The cooperation of gastroenterologists and dentists could lead to an increased detectability of coeliac disease.
Journal of Pediatrics and Child Health
2023
Oral and dental manifestations of celiac disease in children: a case-control study
(Saudi) children with Celiac Disease had a greater number of clinical findings of recurrent aphthous stomatitis (RAS) and dental enamel defects (DEDs) than healthy controls.
BMC
2022
Climate Change
COVID
In this retrospective explorative pilot study, alveolar bone loss and tooth loss are associated with the severity of COVID-19, however they are not independent risk factors.
Advances in Oral and Maxillofacial Surgery
2021
Erectile Dysfunction
Periodontitis is strongly associated with severe ED (SED) treated with penile prostheses, linked to lower endothelial nitric oxide synthase (eNOS) expression in penile tissue. Diabetes and age were identified as additional independent risk factors for SED.
Journal of Periodontology
2025
Poor occlusal support status was significantly associated with Erectile Dysfunction (ED) in community-dwelling men, as opposed to remaining teeth number and periodontal health status.
International Journal of Urology
2024
Eye health
Association between poor oral health and risk of glaucoma
Article:
Eye spy: Exploring the mouth-eye connection (EXCELLENT FOOTNOTES)
The purpose of our study was to explore further the association between chronic periodontitis and glaucoma in a retrospective case-control study design.
Investigative Ophthalmology and Visual Disease
2022
Gastrointestinal Conditions
Dysbiosis of the saliva microbiota is linked to various upper gastrointestinal (UGI) disorders. However, microbiota dysbiosis in subgingival and buccal mucosa sites are specifically associated with the pre-malignant conditions Barrett’s esophagus and gastric atrophy. The oral microbiome, particularly in the subgingival location, might act as biomarkers for UGI cancers.
The American Journal of Gastroenterology
2024
Hip Replacement
Dental diagnoses within 12 months of Total hip arthroplasty (THA) are associated with increased medical complications. Dental diagnoses occurring 12 months after THA are associated with greater implant-related complications, including periprosthetic joint infections (PJIs). Delaying invasive dental procedures for 12 months after THA may be advisable.
The Journal of Athroplasty
2024
HIV
Postmenopausal women with HIV have increased tooth loss
Postmenopausal women with HIV have deterioration of the alveolar trabecular bone microarchitecture that may contribute to greater tooth loss.
BMC Oral Health
2024
Hemophilia
Assessment of Oral Health and Healthy Habits in Adult Patients with Congenital Hemophilia
Patients with hemophilia have an increased risk of developing dental caries.
European Journal of Dentistry
2022
Oral Microbiome
Oral microbiome and pancreatic cancer
Combined symptom and microbiome evaluation may help in the early detection of pancreatic cancer.
World J Gastroenterol.
2020
Pneumonia
Implementing structured oral care at least 2 weeks before surgery reduced postoperative pneumonia and shortened hospital stays across various surgical procedures, suggesting its value as a preventive strategy for improving surgical outcomes.
Plos One
2025
Oral health status of patients with inherited bone marrow failure syndromes
Article:
Hospital-Acquired Pneumonia Is Killing Patients. Yet There Is a Simple Way to Stop It.
Lack of dental care during inpatient stays may be responsible for hundreds of thousands of hospital-acquired infections each year, including nonventilator hospital-acquired pneumonia, which can be fatal in up to 30% of infected patients, especially those lying flat or staying immobile for long periods of time. A greater focus on brushing patients’ teeth regularly during hospital stays is needed, some experts say.
Kaiser Health News
2022
Sickle Cell Anemia
Sickle Cell Disease and Dental Care Access Among Medicaid-Enrolled Youths (Supporting article:
Sleep
Sleep Duration and Risk of Periodontitis-A Systematic Review and Meta-Analysis
The present review indicated that too little sleep duration (≤5 hours) significantly increased the risk of periodontitis. However, the evidence is limited due to cross-sectional design of most studies, hence longitudinal studies should be conducted to support this finding.
International Dental Journal
2024
Sleep apnea
Is periodontitis associated with obstructive sleep apnea? A systematic review and meta-analysis
According to the results, periodontitis has been shown to be associated with mild-to-moderate obstructive sleep apnea (OSA), but not with severe OSA.
Journal of Clinical and Experimental Dentistry
2022
Sjogren’s Syndrome
This study of Sjogren’s Disease patients diagnosed in community practices characterized three different Sjogren’s Disease clinical presentations, which can be used to generate Sjogren’s Disease study cohorts for longitudinal studies using electronic health record data.
Plos One
2023
Thyroid
Associations Between Thyroid Function and Periodontitis: A Machine Learning Approach Using NHANES
Our findings suggest that thyroid parameters, particularly thyroid-stimulating hormone (TSH), might predict risk for periodontitis and serve as its biomarkers, thereby enabling early intervention and personalized patient care.
International Dental Journal
2025
Vaccines
This study demonstrates a statistically significant but modestly increased risk of oral lichen planus (OLP) and oral lichenoid lesions (OLL) following hepatitis B vaccination. Given the small effect size and observational design, the findings should be interpreted as hypothesis-generating.
BMC Oral Health
2025